Estrogen Bioactivation, Genetic Polymorphisms, and Ovarian Cancer
نویسندگان
چکیده
منابع مشابه
Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.
Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a case-control study of 503 incident epithelial ovarian cancer cases at the Mayo Clinic in Rochester, MN, and Jacksonville, FL, and a 48-county...
متن کاملOvarian cancer risk and polymorphisms involved in estrogen catabolism.
Polymorphisms within genes responsible for estrogen catabolism could alter cellular levels of genotoxic 4-hydroxylated catechol estrogens and antiangiogenic 2-methoxyestradiol, thus influencing risk of developing ovarian cancer. We carried out a population-based case-control study of 310 epithelial ovarian cancer cases and 585 controls in African-American and Caucasian women ages 35 to 54 years...
متن کاملAssociation between genetic polymorphisms and ovarian cancer risk.
BACKGROUND The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. PATIENTS AND METHODS A case-control study was conducted to investigate the role of these polymorphisms in ovarian cancer risk. The participants were genotyped for eleven poly...
متن کاملEstrogen receptor-1 genetic polymorphisms for the risk of premature ovarian failure and early menopause.
BACKGROUND The aim of this study was to investigate the role of the estrogen receptor 1 (ESR1) genetic polymorphisms for early menopause that was classified as premature ovarian failure (POF) and early menopause (EM) and to examine whether the associations of ESR1 genetic variants are different for POF and EM. METHODS We selected 100 POF cases and matched 100 EM cases and 200 normal menopause...
متن کاملGenetic Polymorphisms of Estrogen Receptors in Iranian Women with Diabetes and Coronary Artery Disease
Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2005
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-05-0142